Effect of Antidepressants Medications in Glycemic State of Depression Disorders Patients
Abstract
As a result of elevation, depression disorders are prevalent globally; different medication protocols are used for patient therapy. The present study suggested studying the effect of antidepressant medications in a glycemic state of depression disorder patients, and glycemic biomarkers included fasting blood glucose (FBG), Glycated hemoglobin 1c (HbA1c), Insulin level (In), insulin resistance (IR), and insulin sensitivity (IS) were detected, the results show a significant elevation in HbA1c in the patient group than control (p 0.005) and BMI that decreased in patients than control (p 0.041). Other parameters show non-significant slight variations between groups, four types of antidepressants drugs in the present study included clomipramine, Tryptizol, Zyprexa, and Fluxetine. The effect of Antidepressant drugs on some glycemic parameters shows non-significant variation in all parameters, both Zyprexa and Fluxetin causes an elevation in FBG and HbA1c, also fluoxetine causes an elevation in insulin, IR and IS, from present finding can be concluded that fluoxetine causes alteration in glycemic parameters than other drugs and the antidepressants may be contributed in DM incidence.Keywords:
Antidepressants medications, Depression disorders patients, Glycemic stateReferences
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