Synthesis, Characterization, and Study the Biological Activity for Shiff Base and ẞ-lactam Derivatives from 2-amino-4-hydroxy-6-methyl pyrimidine

Authors

  • Rawaa Neamah Department of Chemistry, College of Education, University of Al-Qadisiyah, Al Diwaniyah, Iraq
  • Shaimaa Adnan Department of Chemistry, College of Education, University of Al-Qadisiyah, Al Diwaniyah, Iraq

Abstract

This study includes synthesis and characterization of some shiff base and ẞ-lactam derivatives) by three steps. The first reaction is done on 2-amino-4-hydroxy-6- methyl pyrimidine with 4-amino acetophenone in acid medume to get shiff base derivative 2-(4-amino-benzylidene amino)-6-methylpyrimidin-4-ol) (1). Further to that, (1) reacts with (3, 4-dimethoxybenzal dehyde, 4-methyl benzaldehyde, 4- di methyl ameno benzaldehyde, 4-bromo benzaldehyde, 4-hydroxy benzaldehyde, 4-Nitro benzaldehyde) to get shiff base derivatives (2-7). In the last step (2-7), derivatives react with Chloro acetyl chloride to get ẞ-lactam derivatives (8-13). All these compounds are characterization by fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (¹HNMR), carbon-13 nuclear magnetic resonance (¹³CNMR). After that, study was done on the biological activity for all these derivatives with two kinds of bacteria.

Keywords:

ẞ-lactam, Bacteria, Biological activity, Schiff base

References

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Published

2021-09-03
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Issue

Vol. 12 No. 3 (2021): Volume 12,Issue3

Section

Articles