Association of Apurinic/Apyrimidinic Endonuclease Gene Polymorphism with Some Clinical Features in Systemic Lupus Erythematosus

Authors

  • Mona N. Al-Terehi College of Science, Babylon University, Babylon, Iraq
  • Mohammed A. Jawad Al-Nisour University College, Baghdad, Iraq
  • Abed J. Kadhim Al-Nisour University College, Baghdad, Iraq
  • Ali A. Nayyef Al-Nisour University College, Baghdad, Iraq
  • Thanaa C. Kareem College of Science, Babylon University, Babylon, Iraq

Abstract

The Systemic Lupus erythematosus (SLE) is an autoimmune disease characterized by attack body cells by immune molecules, and the present study was conducted to estimate Apurinic/Apyrimidinic Endonuclease (APE 1) Gene Polymorphism in SLE and associated with clinical features. Deoxyribonucleic acid (DNA) extraction was implemented then allele-specific PCR was used to detect Asp148Glu (rs3136820) in study groups. The results show two alleles (T, G) and three genotyping's (TT, TG, GG), significant association APE1 with SLE disease (X² 9.8609, P 0.019) and more frequent TT genotyping in patients, non-significant association with present oral ulcer (X² 2.6207, P 0.453), non-significant association with malar rash (X² 0.684, p 0.710), and non-significant correlation with painful (X² 1.78, P 0.619). Finally, the association of APE1 with the number of oral ulcers (multiple and single) also non-significant differences (X² 3.6771, P 2.98). the present study shows association APE1 with SLE disease but non-association with clinical features of SLE.

Keywords:

Autoimmune disease, APE1 gene Polymorphism, DNA repair genes, Systemic lupus erythematosus

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Published

2021-08-27
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Issue

Vol. 12 No. 3 (2021): Volume 12,Issue3

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Articles