Synthesis and Identification of Heterocyclic Derivative from 2-amino-4-hydroxy-6-methyl pyrimidine and Study their Biological Activity
Abstract
This study includes the synthesis of some hetrocyclic compounds (oxazepine, ẞ-lactam, imedazolidene, thiazolidine, tetrazole) starting from reacting 2-amino-4-hydroxy-6-methyl pyrimidine with 3-amino acetophenone in acid medium to get schiff base derivative (1). Then (1) react with 4-hydroxy acetophenone in acid medium to get schiff base derivative (2). There after (2) react with (phthalic anhydride, maleic anhydride and succenic anhydride) to give oxazepine derivative (3-5). Also (2) react with (chloroacetyl chloride, glycine, alanine, thioglygolic acid, sodumazide) to get (ẞ-lactam (6), imidazolidine (7,8), Thiazolidine (9), tetrazole (10), respectively. Fourier transform infrared spectroscopy (FTIR), ¹H-Nuclear Magnetic Resonance (¹H-NMR), Carbon-13 nuclear magnetic resonance (13C-NMR) characterize all these derivative. After that, we determine the biological activity for all derivatives toward two kinds of bacteria.Keywords:
ẞ-lactam, Imedazolidene, Oxazepine, Schiff bases, Tetrazole, ThiazolidineReferences
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