X-ray Repair Cross-complementing Group 1 (Arg399Gln) Genotyping in Diabetes Mellitus Type 2 with Hypertension

Authors

  • Hawraa S. Al-Musawi Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq
  • Mohammed A. Jawad Al-Nisour University College, Baghdad, Iraq
  • Mona N. Al-Terehi College of Science, Babylon University, Hillah, Iraq
  • Abed J. Kadhim Al-Nisour University College, Baghdad, Iraq

Abstract

DNA repair genes are one of the important molecules for genome maintains that may be effective by different factors and disease. X-ray Repair Cross-complementing Group 1(XRCC1)gene polymorphism relation with type 2-diabetes mellitus (T2D) with and without hypertension was suggested in present work, polymerase-chain-reaction with the confronting-two-pair primer (PCR-CTPP) was used to detection genotyping of XRCC1, the output shows that (67.5%) was T2D and (32.5%) was T2D with hypertension, genotyping shows two alleles (A, G) and tow genotyping (AG, GG). While AA did not observe in the present study, a non-significant association between T2D and T2D with hypertension (OR0.7813 (0.2024-3.0161), slightly differences appeared in AG and GG between groups. The impact of genotyping in glycemic parameters is non-significant between genotyping within the group except in HbA1C (P 0.007) in the T2D group. The present study concluded that the XRCC1 (Arg399Gln) did not associate with hypertension in T2D patients. Also this polymorphism had no association with the studied biomarkers (diabetic-related parameters, blood pressure parameters, age, and BMI).

Keywords:

Diabetes Mellitus Type 2, Genotyping, Hypertension, X-Ray Repair Cross-Complementing Group 1

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Published

2021-09-11
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Vol. 12 No. 3 (2021): Volume 12,Issue3

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