Hepatoprotective Effect of Lallemantia Royleana Seeds Extract Against Rifadin Toxicity in Male Albino Mice

Abstract

The study aimed to highlight the protective effect of Lallemantia royleana seed extract (Balangu) in protecting the liver against the toxicity of Rifadin. The study was conducted on the male Swiss albino mice (40 mice), aged 5 to 8 weeks and weighed 25 to 30 g, which were divided into four animal groups: the first group orally administrated (0.1 mL) of saline solution (0.9%) for 28 days to represent the control group, second group administrated with 0.1 mL of Rifadine (1.5 mg/kg/day) for 28 days. The third group was administered (0.1 mL) of alcohol extract of Balangu seeds (1%) for 28 days. The fourth group was administrated with seed extract and Rifadin for 33 days. Histopathological changes in the liver tissue of the experimental groups were reported as a loss of the radial arrangement of the hepatic cords in the central lobular region and in the surrounding areas with moderate/severe congestion in the drug-treated group, the seed and drug extract group, the retention of hepatic cords were observed in the radial regulation, especially in the area around the central vein with moderate blood congestion (Mild/ Moderate Congestion) in the central veins, and the presence of many numbers of Balone-Shape cells and Hepatic Vacuolated cells. The histological composition of the Balangu seed extract group was similar to that of the control group, but there is infiltration of mononuclear leukocytes in the central lobular region.