Nanotherapy Technology Based Treatment and Drug Delivery Management for Osteoarthritis: A Review
Abstract
Osteoarthritis (OA) is a chronic disease that affects the cartilage in the joint owing to the cause of age factors, obesity deficiency, genetic disorder, and significantly it reduces the effect of motions in normal functional activities. Today, various treatment methods are followed to prevent this disease's adverse effects, such as exercise, surgery, topical and oral medications, steroidal injections, stem cell therapy, and viscosupplementation. Nevertheless, nonsteroidal anti-inflammatory drugs (NSAIDs) are suggested to overcome the intensity of pain, but it is still limited due to various side effects. Although there is no proper treatment adopted for the long term to permanently eradicate this disease, it is essential to know about the manifestation in both pharmacologic and non-pharmacologic treatments for OA. In spite of various treatments implemented there are many challenges that still remain unclear to completely rehabilitate from this disease, such as the origin of this disease and mechanism. This review aimed to discuss and summarize the significant progression in different treatment methods for OA, the importance of nano therapy, drug delivery systems for OA and highlighted the utilization of carbon nanotubes in OA therapy in order to bring out the noteworthy of nano therapy and demonstrating the importance of various therapeutic strategy followed for OA disease. Hence, a better understanding of treatment modalities for OA will pave the path to emerge new therapeutics in future clinical trials to control this disease and perspicuous view on choosing the treatment methods.Keywords:
Drug delivery system, Nanotherapy, Non-pharmacology, Osteoarthritis, PharmacologyReferences
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