Development and Characterization of Ketoprofen Loaded Protransfersome by Using Sodium Cholate for Transdermal Delivery
Abstract
The study was aimed to characterize protransfersome gel as TDDS of ketoprofen for effective and sustain deliver of drug. The various formulation parameters were optimized by preparing 9 formulations using Sodium cholate as edge activator. All protransfersome formulations were characterized and found that, in physical appearance protransfersome gel was Yellowish semisolid compact mass and the mean particle size of transfersome varied from 1027-1209 nm. TEM micrographs transfersome suspension showed that the vesicles have a uniform spherical shape with a smooth surface. The formulation PTC3-I have higher rate to produce transfersome than all formulations (10.331±0.221) X 103. Formulations with cholesterol have good entrapment capacity and formulations with isopropanol have a little advantage of higher entrapment in comparison with others either with butanol or ethanol. Release rate study through cellophane membrane indicate that the % cumulative release in 48 hr was found ranging in 34%-64%, PTdC3-I formulation has shown highest percentage release.Keywords:
protransfersome, ketoprofen, sodium cholateReferences
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