UV Spectrophotometric Estimation of Satranidazole in Periodontal Gels
Abstract
A simple, precise and economical UV method has been developed for the estimation of Satranidazole in periodontal gels. Satranidazole has the absorbance maxima at 319 nm in McIlvaine buffer pH 6.6.Beer's law was obeyed in the range 1-40µg/ml with correlation coefficient (n = 6) ≥ 0.9996.The proposed methods were successfully applied for the simultaneousdetermination of Satranidazolein gel dosage form. The developed method was validated for accuracy and precision. Percent recovery for Satranidazole was found in the range of 98.14% to 100.68 %. A high percentage recovery indicates the high accuracy of the method. This method has the advantage of quicker turnaround time of sample analysis and less cost involved. It can act as an alternative for HPLC method for the routine use in quality control laboratories of pharmaceutical industry for estimation of Satranidazole.Keywords:
Gel, In-vitrodissolution, Satranidazole, UV spectrophotometryReferences
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