Simultaneous Spectrophotometric Estimation Of Dexrabeprazole And Domperidone In Capsule Dosage Form
Abstract
Three UV spectrophotometric methods for the simultaneous determination of dexrabeprazole (DEXRAB), and domperidone (DOM), in capsules were developed in the present work. Method I is simultaneous equation method, wavelength selected are 258.5 nm (λmax for dexrabeprazole) and 286.5 nm (λmax for domperidone). Method II involves multicomponent mode of analysis, wavelength selected are 258.5 nm (λmax for dexrabeprazole) and 286.5 nm (λmax for domperidone). Method III is area under curve method, wavelength range selected are 263.5-253.5 nm for dexrabeprazole and 291.5-281.5 nm for domperidone respectively. All the methods were found linear between 5-35 µg/ml for dexrabeprazole and 10-70 µg/ml for domperidone. The accuracy and precision of the methods were determined and validated stastically which showed no significant difference between the results obtained by the three methods. The proposed methods are highly sensitive, precise and accurate and therefore can be used for its intended purpose.Keywords:
Dexrabeprazole, domperidone, simultaneous equation method, multicomponent mode of analysis, area under curve methodReferences
1. Bodhankar SL, Jain BB, Ahire BP, Daude RB, Shitole PP,2006. The effect of rabeprazole and its isomers on histamine and aspirin induced ulcers in rats. Indian J Pharmacol; 38, 357-8.
2. Gandhi SV, Sabnis SS, Dhavale ND, Jadhav VY, Tambe SR, 2008.Spectrophotometric Simultaneous Determination of Rabeprazole Sodium and Domperidone in Combined Tablet Dosage Form British Eurasian Journal of Analytical Chemistry, 3 (2).
3. British Pharmacopoeia 2008. British Pharmacopoeia Commission Office, London: U.K., Vol I, 752-6.
4. Sivasubramanian L, Anilkumar V, 2007. Simultaneous HPLC estimation of omeprazole and domperidone from tablets, Indian Journal of Pharmaceutical Sci, 69, 674-6.
5. Patel B, Dedania Z, Dedania R, Chetan R, Vidyasagar G and Mehta RS, 2009.Simultaneous Estimation of Lansoprazole and Domperidone in Combined Dosage Form by RP-HPLC, Asian J. Research Chem, 2,210-12.
6. Sivakumar T., Manavalan R., Valliappan K. 2008. Computer-assisted optimization of liquid-liquid extraction for HPLC analysis of domperidone and pantoprazole in human plasma, Acta Chromatographica, 20, 549-62.
7. Park CW, Rhee YS, Go B W, Kam SH, Lee KH, Lee HS, Park ES. 2008. High performance liquid chromatographic analysis of rabeprazole in human plasma and its pharmacokinetic application, Arch Pharm Res, 31, 1195-9.
8. Karthik A, Subramanian G, Kumar A Ranjith, Udupa N ,2007.Simultaneous estimation of paracetamol and domperidone in tablets by reverse phase HPLC method, Indian J Pharm Sci, 69, 142-4.
9. Patel BH; Patel MM; Patel JR; Suhagia BN, 2007. HPLC Analysis for Simultaneous Determination of Rabeprazole and Domperidone in Pharmaceutical Formulation,Journal of Liquid Chromatography & Related Technologies, 30, 439-445.
10. Gandhi SV, Sabnis SS, Dhavale ND Jadhav VY, 2008. Jourrnal of AOAC International, 91,344-8.
11. Argekar AP, Shah SJ,1999.Simultaneous determination of cinnarizine and domepiridone maleate from tablet dosage form by reverse phase ion pair high performance liquid chromatography, J.Pharm. Biomed. Anal, 19;813-7.
12. Patel B. H., Suhagia B. N., Patel M. M., Patel J. R. 2007. Determination of Pantoprazole, Rabeprazole, Esomeprazole, Domperidone and Itopride in Pharmaceutical Products by Reversed Phase Liquid Chromatography Using Single Mobile Phase, Chromatographia, 65,743-8.
13. Kalra K, Naik S, Jarmal Gand Mishra N , 2009. Spectrophotometric Method for Simultaneous Estimation of Paracetamol and Domperidone in Tablet Formulation, Asian J. Research Chem, 2, 112-5.s
14. RajendraprasadY,K.K.Rajasekhar,V.Shankarananth,H.V.Yamini krishna, S.Saikumar, P. Venkata raghav reddy,2009. Spectrophotometric method for the estimation of domperidone in bulk and pharmaceutical formulations, Journal of Pharmacy Research, 2,1593-4.
15. Charde M; Walode S; Tajne M; Kasture A,2006. UV- spectrophotometric estimation of ranitidine and domperidone in tablet formulations, Indian J Pharm Sci, 68, 658-9.
16. Amin A S, Ragab G H,2003. Spectrophotometric Methods for the Determination of Anti-Emetic Drugs in Bulk and in Pharmaceutical Preparations, Anal Sci, 19; 747-51.
17. Gandhi SV, Khan SI., Jadhav RT., Jadhav SS., Jadhav GA, 2009. High-Performance Thin-Layer Chromatographic Determination of Rabeprazole Sodium and Domperidone in Combined Dosage Form, 92,1064-7.
18. Zhan Li, Jing Yao, Ziqiang Zhang, and Luyong Zhang, 2009. Simultaneous Determination of Omeprazole and Domperidone in Dog Plasma by LC-MS Method, Journal of Chromatographic Science, 47, 881-4.
19. S.S.Chitlange, S.Ranjana , S.B.Wankhede and A.A.Kulkarni, 2009. Spectrophotometric Methods for simultaneous estimation of Nimesulide and Drotaverine, Int. J. chem. Tech Res., 1, 135-8.
20. S.S.Chitlange, S. Ranjana , S.B.Wankhede and A.A.Kulkarni, 2009.Spectrophotometric Methods for simultaneous estimation of Dexibuprofen and Paracetamol, Asian J. Research Chem, 2, 30-3.
21. ICH Harmonised Tripartite Guideline, 2005. Validation of Analytical Procedures: Text and Methodology Q2 (R1).
Published
Abstract Display: 0 
PDF Downloads: 0 
