Stability Indicating RP-HPLC Method for the Estimation of Trifluoperazine Hydrochloride as API and Estimation in Tablet Dosage Forms
Abstract
A new stability indicating method was developed for the estimation of trifluoperazine HCl in API, this method was also successfully utilized for the estimation of drug in tablet dosage forms. All the methods were utilized for the degradation of drug i.e. 0.1 N HCI, 0.1 N NaOH, 3 % H2O2, thermal and photodegradation. Drug peak was found to be seperated from all the degradants with resolution of more then two. This method was also used for the estimation of Trifluoperazine HCl in tablet dosage forms. The method was found to be simple, precise, specific and accurate. Developed HPLC method is able to separate all degradants produce form any stress condition from drug peak by resolution of more than 2. The order of stability trifluoperazine HCl was found to be H2O2Keywords:
TFH, HPLC, Forced degradation, Stability indicating HPLCReferences
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