Spectrophotometric determination of Metclopramide Hcl using Solochrome black-T

Abstract

A simple and sensitive visible spectrophotometric method have been developed for the quantitative determination of Metclopromide HCl in its different dosage form (tablet, oral solution and injection). The method is based on the ion pair extraction with chloroform at pH 2.0 using Solochrome black -T as the ion pairing reagent. The spectrophotometric measurement was carried out at the absorption maximum at 505 nm. Beer's law was obeyed in the concentration range of 5- 50 µg/ml with the reagent. The results obtained with the proposed method are in good agreement with the labeled amounts when marketed pharmaceutical preparations are assayed. The recovery was in the range of 98.5-101.5%. Results obtained are statistically validated and found to be reproducible.