Spectrophotometric Estimation of Fluvoxamine Maleate in Tablets Using Hydrotropic Agent
Abstract
Several techniques are used to increase the aqueous solubilities of poorly water soluble drugs. Hydrotropic solubilization technique is one of them. In the present investigation hydrotropic solution of Urea (10M) has been used as a solubilizing agent to solubilize poorly water soluble drug. Fluvoxamine maleate shows maximum absorbance at 271 nm. Beer's law was obeyed in the concentration range of 5-25 µg/ml. Results of analysis were validated statistically and by recovery studies. The proposed method is now simple, new, environmentally friendly, accurate and cost-effictive and successfully employed in routine analysis of fluvoxamine maleate tablets. Hydrotropic agent urea did not interfere in spectrophotometric determination.Keywords:
Fluvoxamine Maleate, Hydrotropy, Urea, organic solvent, SpectrophotometerReferences
1. Maheshwari RK. Analysis of frusemide by application of hydrotropic solubilization phenomenon. Indian Pharmacist 2005;4:55-58
2. Maheshwari RK. Spectrophotometric determination of cefixime in tablets by hydrotropic solubilization phenomenon. Indian Pharmacist 2005;4:63-68
3. Maheshwari RK. A novel application of hydrotropic solubilization in the analysis of bulk samples of ketoprofen and salicylic acid. Asian J Chem 2006;18;393-96.
4. Maheshwari RK. New application of hydrotropic solubilization in the spectrophotometric estimation of ketoprofen in tablet dosage form. Pharma Rev 2005; 3:123-25.
5. Maheshwari RK. Novel application of hydrotropic solubilization in the Spectrophotometric analysis of tinidazole in dosage form. Asian J Chem 2006;18;640-44.
6. Maheshwari RK. Application of hydrotropic solubilization in the analysis of aceclofenac. Asian J Chem 2006; 18:1572-74.
7. Maheshwari RK. Spectrophotometric analysis of amoxicillin in tablets using hydrotropic solubilization technique. Asian J Chem 2006;18:3194-96.
8. Maheshwari RK, Chaturvedi SC, Jain NK. Application of hydrotropy in spectrophotometric determination of pharmaceutical dosage form. Indian Pharmacist 2005;42:760-63
9. Maheshwari RK, Chaturvedi SC, Jain NK. Application of hydrotropy in spectrophotometric analysis of hydrochlorothiazide tablets. Indian Pharmacist 2005;42:541-44
10. Maheshwari RK, Chaturvedi SC, Jain NK. Novel spectrophotometric estimation of some poorly water soluble drugs using hydrotropic solubilizing agents. Indian J Pharm Sci 2006; 68:195-58.
11. Maheshwari RK, Chaturvedi SC, Jain NK. Novel application of hydrotropic solubilization in the quantitative analysis of some NSAIDs and their solid dosage forms. Indian J Pharm Sci 2007; 69:101-06.
12. Maheshwari RK, Chaturvedi SC, Jain NK. Novel application of hydrotropic solubilizing additives in the estimation of aspirin in bulk sample and tablets. Int J Pharm Exicip 2005;4:84-88
13. Maheshwari RK, Pandey SP, Lovlekar A, Chavda V, Ajmera A, Gupta HM. Novel application of hydrotropic solubilization in the spectrophotometric analysis of cephalexin in solid dosage form. Asian J Chem 2006; 18:1451-4.
14. Maheshwari RK, Dewangan A, Soni PK, Kansagra PK, Jain SK. Novel application of hydrotropic solubilization in the spectrophotometric analysis of paracetamol tablet dosage form. Asian J. Chem. 2006; 18:2879-82.
15. Maheshwari RK. Novel application of hydrotropic solubilization in the spectrophotometric analysis of piroxicam in solid dosage form. Indian Drugs 2006; 43:683-85.
Published
Abstract Display: 0 
PDF Downloads: 0 
